This marks the beginning of God's covenant with Abram (later named Abraham) and the promise of a great nation that would be blessed and would bless others. In this passage, God instructs Abram to leave his homeland, his relatives, and his father's household, and to go to a land that God will show him. God promises to make Abram into a great nation, bless him, and make his name great, and in turn, Abram is to be a blessing to others.
The passage highlights the theme of faith and obedience to God's calling, as Abram immediately obeys God's command and sets out on his journey with his wife Sarai and his nephew Lot. It also emphasizes the importance of God's promises and his faithfulness to fulfill them.